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Type 2 Diabetes Mellitus: A Possible Surgically Reversible Intestinal Dysfunction

We present a literature review of the possible mechanisms of early normalization of glycemic homeostasis
after bariatric surgery, including intestinal gluconeogenesis, increased antidiabetogenic signals from L cells located in
the distal small intestine, and impaired secretion of diabetogenic signals in the upper part of the small intestine. Adding
to these potential mechanisms, unknown factors that regulate insulin sensitivity may be involved and altered by bariatric
surgery. This review discusses the various hypotheses about the mechanisms of glycemic control after bariatric surgery involving
intestinal bypass. Further research is essential to better understand these mechanisms and to identify potential new mechanisms
that might help in developing less invasive and safer alternativ…