,

Overexpression of 11β�hydroxysteroid dehydrogenase type 1 in visceral adipose tissue and portal hypercortisolism in non�alcoholic fatty liver disease

ConclusionMurine NAFLD is associated with portal hypercortisolism and11β�HSD1 overexpression in VAT. In humans, 11β�HSD1 VAT expression was associated with the presence of NAFLD. Thus, local corticosteroid production in VAT may contribute to NAFLD pathogenesis. (Source: Liver International)