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Ghrelin Normal After Gastric Bypass

Roux-en-Y gastric bypass surgery restored normal regulation of the appetite hormone ghrelin, an analysis of the STAMPEDE trial found.

In addition, bypass patients lost more belly fat and had improved insulin secretion compared with patients who had sleeve gastrectomy, even though their total weight loss was the same, according toSangeeta R. Kashyap, MD, of the Cleveland Clinic, and colleagues.

The finding that bypass surgery patients had greater suppression of acylated ghrelin two years after surgery and had better metabolic outcomes, including pancreatic beta-cell function, suggests that ghrelin suppression may play a key role in improved glucose control, they wrote in the International Journal of Obesity, published online Nov. 22.

Read full article: http://www.medpagetoday.com/Endocrinology/Obesity/43097

Primary source: International Journal of Obesity
Source reference: Malin SK, et al “Improved acylated ghrelin suppression at 2 years in obese patients with type 2 diabetes: effects of bariatric surgery versus standard medical therapy”Int J Obes 2013 DOI: 10.1038/ijo.2013.196.